Adaptive Platform Trials (APTs) are a flexible trial design that enable multiple interventions within different treatment modalities (domains) to be compared simultaneously in one or more patient groups where interventions be added or removed as the study progresses based on pre-defined decision rules. APTs offer efficiency in time and cost compared with conventional designs, but are much more complex to design and operate. This workshop, presented by a range of researchers with experience in APTs, provides an opportunity to learn from others and to discuss issues in designing and conducting APTs.

The morning will focus on operational issues in APTs, covering topics such as sponsorship, ethics, contracts, databases, consumer engagement funding and creating a community of practice. In the afternoon, we will focus on statistical issues of simulation for trial design, statistical documentation and the development, validation and analysis of ordinal outcomes.

The workshop is aimed at researchers and statisticians working in or considering embarking on establishing an APT. Working knowledge of APTs will be assumed.

This session will feature presenters from diverse fields – ethics, qualitative research, consumer and community involvement, implementation science, Indigenous health – to prompt the audience to reflect on WHAT intersectionality is and HOW it can be applied in clinical trials to make research and healthcare more socially aware, inclusive and just.

Facilitated by: Prof Nik Zeps, Dr Bec Jenkinson, Dr Mark Liu & Prof Dan McAulley

This safe and creative workshop will deliver a facilitated conversation that explores both the barriers experienced by Indigenous Australians in accessing clinical trials and the opportunities that can address these existing inequities and increase their participation in research.

The workshop facilitators will lead participants through an expert-guided series of presentations and group discussions that identify the ways in which culturally appropriate and safe services and staff can positively impact on the lives of Indigenous participants and their families. The facilitation team includes expert knowledge holders from the Aboriginal heath service sector, Indigenous genomics research, Indigenous data sovereignty and governance and the pharmaceutical industry.

This is a unique opportunity to learn and apply new and co-designed knowledge and methods within clinical trials environments to increase an under-represented clinical trials participant cohort – Indigenous Australians.